Forest borders, clearings, moist forests and floodplains.

The calyx lobes, besides running a little longer than in Agastache nepetoides, are also more narrowly lance-acute, less veiny, and less firm in texture; however, these are rather subjective characters. Agastache scrophulariifolia does have a somewhat larger inflorescence; when pressed the larger inflorescences (calyx tip-calyx tip) are ca. 14–20 mm wide, those of A. nepetoides generally run 10–16 mm wide.

Recent collections are few.